주요활동
[최근 주요 연구논문 (2010-2011)]
1. 1H-NMR-Based Metabolomics Study of Cerebral Infarction. Jee Youn Jung, Ho-Sub Lee, Dae-Gill Kang, No Soo Kim, Min Ho Cha, Ok-Sun Bang, Do Hyun Ryu, Geum-Sook Hwang*, Stroke 2011, 42(5), 1282-1288
2. 1H-NMR-based Metabolomic Profiling in Mice Infected with Mycobacterium tuberculosis, Ji-Hyun Shin, Ji-YoungYang, Bo-YoungJeon, Yoo JeongYoon, Sang-NaeCho, Yeon-HoKang, Do HyunRyu, Geum-Sook Hwang*, J. Proteome. Res. 2011, 10, 2238
3. Characterization of Dandelion Species using 1H NMR-and GC-MS-based Metabolite Profiling. Youngae Jung, Yun Gyong Ahn, Ho Kyoung Kim, Byeong Cheol Moon, A Yeong Lee, Do Hyun Ryu and Geum-Sook Hwang*, Analyst. 2011, 136, 4222
4. Metabolite Profiling of Angelica Gigas from Different Geographical Origins Using 1H NMR and UPLC-MS Analyses. Eun Jin Kim, Joseph Kwon, Seong Hwa Park, Chiyoul Park, Young-Bae Seo, Hyun-Kyoo Shin, Ho Kyoung Kim, Kwang-Sik Lee, Sang-Yun Choi, Do Hyun Ryu, and Geum-Sook Hwang*, J Agric Food Chem. 2011, 59(16), 8806-15.
5. Proteomic and Metabolomic Analysis of H(2)O(2)-induced Premature Senescent Human Mesenchymal Stem Cells. Ji-Soo Kim, Eui-Jin Kim, Hyun-Jung Kim, Ji-Young Yang, Geum-Sook Hwang and Chan-Wha Kim, Exp. Gerontol. 2011, 46, 500
6. Metabonomic Understanding of Probiotic Effects in Humans With Irritable Bowel Syndrome. Young-Shick Hong, Kyoung Sup Hong, Min-Hwa Park, Young-Tae Ahn, Jung-Hee Lee, Chul-Sung Huh, Jaekyung Lee, In-Kyoung Kim, Geum-Sook Hwang*, Joo Sung Kim, Journal of Clinical Gastroenterology 2011, 45(5), 415-525
7. A multianalytical Approach for Determining the Geographical Origin of Ginseng using Strontium Isotopes, Multielements, and 1H NMR analysis. A-Reum Lee, Mukesh Gautam, Jahan Kim, Woo-Jin Shin, Man-Sik Choi, Yeon-Sik Bong, Geum-Sook Hwang,* and Kwang-Sik Lee*, J Agric Food Chem. 2011, 59(16), 8560
8. 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure 1H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure. Seok-Min Kang, Jong-Chul Park, Min-Jeong Shin, Hyeran Lee, Jaewon Oh, Do Hyun Ryu, Geum-Sook Hwang*, Ji Hyung Chung*, Clin.Biochem. 2011, 44, 293-299
9. 1H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Choi, Jinho Kim, Ho-Sub Leeb, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang*, Toxicol. Lett. 2011, 200, 1-7
10. Dialysis modality-dependent changes in serum metabolites:accumulation of inosine and hypoxanthine in patients on haemodialysis. Ji-Young Choi, Yoo Jeong Yoon, Hee-Jeong Choi, Sun-Hee Park, Chan-Duck Kim, In-San Kim3, Tae-Hwan Kwon, Jun-Young Do, Sung-Ho Kim, Do Hyun Ryu, Geum-Sook Hwang* and Yong-Lim Kim*, Nephrol. Dial. Transplant. 2011, 26,1304
11. Novel biodegradation pathways of cyclohexane by Rhodococcus sp. Taewoo Yia, Eun-Hee Leea, Yun Gyong Ahnb, Geum-Sook Hwangb, Kyung-Suk Cho, J Hazard Mater. 2011, 191(1-3), 393-6.
12. 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice. Il Yong Kim, Jeeyoun Jung, Mi Jang, Yun Gyong Ahn, Jae Hoon Shin, Ji Won Choi, Mi Ra Sohn, Sun Mee Shin, Dae-Gil Kang, Ho-Sub Lee, Yun Soo Bae, Do Hyun Ryu, Je Kyung Seong, Geum-Sook Hwang* Biochem. Biophys. Res. Commun. 2010, 403(3-4), 428-34
13. Metabonomic analysis of serum metabolites in kidney transplant recipients with cyclosporine A- or tacrolimus-based immunosuppression. Chan-Duck Kim, Eun-Young Kim, Hanna Yoo, Jae Won Lee, Do Hyun Ryu, Dong Woo Noh, Sun-Hee Park, Yong-Lim Kim, Geum-Sook Hwang* and Tae-Hwan Kwon*, Transplantation 2010, 90(7),748-756
14. Discrimination of the Geographical Origin of Beef by 1H NMR-Based Metabolomics Youngae Jung, Jueun Lee, Joseph Kwon, Kwang-Sik Lee,§, Do Hyun Ryu and Geum-Sook Hwang*, J Agic Food Chem. 2010 58,10458-10466
15. Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by 1H-NMR-based metabonomics. Geum-Sook Hwang, Ji-Young Yang, Do Hyun Ryu, and Tae-Hwan Kwon* Am J Physiol Renal Physiol 2010, 298,F461-470
16. 1H NMR-based Metabonomic Assessment of Probiotic Effects in a Colitis Mouse Model. Young-Shick Hong, Young-Tae Ahn, Jong-Cherl Park, Jung-Hee Lee, Hoyong Lee, Chul-Sung Huh, Dong-Hyun Kim, Do Hyun Ryu, and Geum-Sook Hwang*, Arch Pham Res 2010, 33(7) 1091-1101
17. Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model. Kyu-Bong Kim, Ji-Young Yang, Seung Jun Kwack, Kui Lea Park, Hyung Sik Kim, Do Hyun Ryu, Yeon-Joo Kim, Geum-Sook Hwang*, Byung Mu Lee*. J Toxicol Environ Health 2010, 73,1420-1430
18. Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831. Eun-Hee Lee, Jaisoo Kim, Kyung-Suk Cho, Yun Gyong Ahn, Geum-Sook Hwang. Environ Sci Pollut Res Int. 2010, 17(1),64-77
[특허]
1) 산화성 스트레스 및 저산소증의 진단을 위한 혈액 투석 환자의 혈청 내 이노신 및 하이포잔틴 검출 방법 10-2010-0105418 특허 출원 (2010. 10.27)
2) 쇠고기 원산지 판별용 바이오마커 10-2009-0130392 특허 출원 (2009. 12. 24)
3) Novel beta substituted morita-baylis-hillman derivatives PCT 국제 특허 출원 PCT/KR2008/002379 (2008. 04. 25)
[활동분야]
1) 자기공명학회 및 질량분석학회
2) 세계 Metabolomics Society
3) 한국 대사체연구회
[주요수행과제]
1) 대사체 프로파일링 연구를 통한 질환 마커 발굴 및 생체 메커니즘 규명-기초연 (2011. 1 - 2013.12)
2) 신부전 진단 및 치료를 위한 NMR 기반 대사체/화학통계 기술 개발-교과부 (2010.6 - 2015.6.)
3) 대사체를 이용한 식품원산지 판별 연구-기초연 (2009. 1. - 2011. 12.)
4) LC/NMR/MS 장비를 활용한 환경친화형 신소재 개발 - 중기청 (2010. 5. - 2012. 5)
[수상경력]
- 과학의날 국무총리 표창 2011. 04
- 기초기술연구회 다빈치상 2010. 02.
